Abstract： Objective： To observe the clinical effect of Zhuizhen Tongdu Xunjing Therapy Decoction combined with Tongjing Jiejing Decoction on limb spasticity after cerebral infarction. Methods： A total of 86 patients with limb spasticity after cerebral infarction were selected and divided into the control group and the observation group according to the random number table method， with 43 cases in each group. Both groups received conventional treatments such as anti-spastic medicine and rehabilitation training. The control group was added with Tongjing Jiejing Decoction based on conventional treatment， and the observation group was added with Zhuizhen Tongdu Xunjing Therapy based on the treatment of the control group. Both groups were treated for 2 months. The improvement of limb spasticity [Modified Ashworth Scale (MAS)]， neurological function indexes [neuron-specific enolase (NSE)， central nervous system specific protein (S100β)] and ability of daily living [modified Barthel Index (MBI)] were compared before and after treatment between the two groups. Results： After treatment， the MAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the MAS score in the observation group was lower than that in the control group (P＜0.05). After treatment， the levels of NSE and S100β in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of NSE and S100β in the observation group were lower than those in the control group (P＜0.05). After treatment， the MBI scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the MBI score in the observation group was higher than that in the control group (P＜0.05). Conclusion： Zhuizhen Tongdu Xunjing Therapy Decoction combined with Tongjing Jiejing Decoction can improve the neurological function of patients with limb spasticity after cerebral infarction， reduce spasms，and improve the ability of daily living.