Abstract： Objective： To observe the curative effect of the therapy of Buyang Huanwu Decoction combined with Jiejing Pingheng acupuncture method on post-stroke hemiplegia and its effects on serum histone deacetylase 3 (HDAC3) level. Methods： A total of 120 patients with post-stroke hemiplegia were randomly divided into the control group and the treatment group，with 60 cases in each group. The control group was treated with routine western medicine， and the treatment group was additionally treated with Buyang Huanwu Decoction based on the treatment of the control group. The changes in clinical effects， muscle strength of flexors and extensors of the body，gait and serum HDAC3 levels in the two groups were observed. Results：The total effective rate was 86.67% in the treatment group，and 68.33% in the control group，the difference being significant (P＜0.05). After treatment，there were no great changes in the root mean square (RMS) values of surface electromyography of muscle strength of rectus abdominis and erector spinae on the healthy side in the two groups when compared with that before treatment (P＞0.05)； the RMS values of muscle strength of rectus abdominis and erector spinae on the affected side in the two groups were increased when compared with those before treatment (P＜0.05)，and the above RMS values in the treatment group were higher than those in the control group (P＜0.05). After treatment， the stride frequency， pace and proportion of stride length in the two groups were increased when compared with those before treatment (P＜0.05)， and the above three indexes in the treatment group were higher than those in the control group (P＜0.05). After treatment， the serum HDAC3 levels in the two groups were decreased when compared with those before treatment (P＜0.05)， and the serum HDAC3 level in the treatment group was lower than that in the control group (P＜0.05). Conclusion： The therapy of Buyang Huanwu Decoction combined with Jiejing Pingheng acupuncture method has a greate curative effect on patients with post-stroke hemiplegia， which can significantly improve the muscle strength of flexors and extensors of the body and gait，and decrease the serum HDAC3 level.