Abstract： Objective： To observe the clinical effect of Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription for chronic urticaria with wind-heat syndrome. Methods：A total of 106 cases of patients with chronic urticaria with wind-heat syndrome were selected and divided into the control group and the trial group according to random number table method， with 53 cases in each group. The control group was treated with Loratadine，and the trial group was additionally treated with Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription based on the treatment of the control group. Both groups were treated for 2 weeks and followed up for 12 weeks. The clinical effects，scores of number of wheal and itching severity， levels of serum inflammatory factors [tumor necrosis factor- α (TNF- α)， interleukin-17 (IL-17)，and interleukin-23 (IL-23)]，and the incidence of adverse reactions were compared between the two groups. Results：After 2-week treatment，the total effective rate was 96.23% in the trial group，higher than that of 83.02% in the control group (P＜0.05). After 2-week treatment，the scores of number of wheal and itching severity in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of number of wheal and itching severity in the trial group were lower than those in the control group (P＜0.05). After 2-week treatment， the levels of serum TNF- α， IL-17， and IL-23 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of serum TNF-α，IL-17，and IL-23 in the trial group were lower than those in the control group (P＜0.05). During the treatment， the incidence of adverse reactions was 13.21% in the trial group and 9.43% in the control group，there being no significance in the difference (P＞0.05). Conclusion：Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription for chronic urticaria with wind-heat syndrome can effectively improve patients' symptom and reduce levels of inflammatory factors with good safety.