Abstract：Objective：To observe the clinical effect of Bushen Shengsui Yizhi Decoction combined with Sodium Oligomannate Capsules on senile dementia caused by Alzheimer's disease of insufficiency in the sea of marrow type. Methods：A total of 124 cases of patients with Alzheimer's disease of insufficiency in the sea of marrow type were selected and divided into the treatment group and the control group according to the random number table method，with 62 cases in each group. The treatment group was treated with Bushen Shengsui Yizhi Decoction combined with Sodium Oligomannate Capsules， and the control group was treated with Sodium Oligomannate Capsules. The scores of Mini-Mental State Examination (MMSE)， the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog)， Hasegawa's Dementia Scale (HDS)， and Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) scale before and after treatment，as well as clinical effects were compared between the two groups. Results：After treatment， the total effective rate was 90.32% in the treatment group and 75.81% in the control group，the difference being significant (P＜0.05). After treatment， MMSE scores in the two groups were increased when compared with those before treatment (P＜0.05)，and MMSE score in the treatment group was higher than that in the control group (P＜0.05)；ADAS-cog scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and ADAS-cog score in the treatment group was lower than that in the control group (P＜0.05). After treatment， HDS scores in the two groups were increased when compared with those before treatment (P＜0.05)，and HDS score in the treatment group was higher than that in the control group (P＜0.05)；BEHAVE-AD scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and BEHAVE-AD score in the treatment group was lower than that in the control group (P＜0.05). Conclusion： Bushen Shengsui Yizhi Decoction combined with Sodium Oligomannate Capsules has good clinical effects in the treatment of senile dementia caused by Alzheimer's disease of insufficiency in the sea of marrow type and can improve cognitive and dementia symptoms.