Abstract： Objective： To observe the clinical effect of fumigation of Qushi Tongluo Prescription combined with acupotomy on lumbar disc herniation (LDH) of damp-heat type. Methods：A total of 66 LDH patients of damp-heat type were selected and divided into the control group and the observation group according to the random number grouping method， with 33 cases in each group. The control group was given acupotomy， and the observation group was given fumigation of Qushi Tongluo Prescription combined with acupotomy. Both groups were treated for 4 weeks. The clinical effects， scores of Visual Analogue Scale (VAS)， scores of low back pain， Japanese Orthopaedic Accociation (JOA) scores， and levels of tumor necrosis factor- α (TNF- α) and interleukin-1β (IL-1β) were compared between the two groups. Results： After treatment， the total effective rate was 93.94% in the observation group， and 75.76% in the control group，the difference being significant (P＜0.05). After treatment，the VAS scores of low back pain in the two groups were decreased when compared with those before treatment (P＜0.05)， and the VAS score of low back pain in the observation group was lower than that in the control group (P＜ 0.05). After treatment， the JOA scores in the two groups were increased when compared with those before treatment (P＜0.05)，and the JOA score in the observation group was higher than that in the control group (P＜0.05). After treatment，the levels of TNF-α and IL-1β in the two groups were decreased when compared with those before treatment (P＜0.05)，and the two levels in the observation group were lower than those in the control group (P＜0.05). Conclusion：Fumigation of Qushi Tongluo Prescription combined with acupotomy has a significant effect on LDH of damp-heat type，which can effectively reduce the levels of serum inflammatory factors，relieve pain symptoms and improve lumbar function activities.