Abstract： Objective： To observe the therapeutic effect of the therapy of Jianpi Gutai Prescription combined with conventional therapy on fetal growth restriction (FGR). Methods： A total of 100 pregnant women diagnosed with FGR through prenatal examinations were selected as study objects，and randomly divided into the treatment group and the control group，with 50 cases in each group. The two groups were treated with conventional therapy，and the treatment group was additionally given Jianpi Gutai Prescription. Both groups were treated for 2 weeks. The traditional Chinese medicine (TCM) scores evaluated， uterine height increase，abdominal circumference increase，the ratio of umbilical artery systolic blood pressure to diastolic blood pressure (S/D) and fetal abdominal circumference increase， femur length increase， double parietral diameter increase were statistically analyzed. The levels of Angoietin 1 (Ang- Ⅰ)， Angoietin 2 (Ang- Ⅱ) and tyrosine kinase receptor 2 (Tie2) were detected. The clinical effects in the two groups were also compared. The pregnancy outcome and the incidence rates were calculated. Results： After 2 weeks of treatment， the total effective rate in the treatment group was higher than that in the control group (P＜0.05). The TCM scores in the two groups were decreased when compared with those before treatment (P＜0.05)；the TCM scores in the treatment group was lower than that in the control group (P＜0.05). The ratio of umbilical artery S/D was lower than that before treatment， differences being significant (P＜0.05). The increase of uterine height and abdominal circumference in the treatment group was greater than that in the control group，and the ratio of umbilical artery S/D was lower than that in the control group，differences being significant (P＜0.05). The growth rates of fetal abdominal circumference， femur length and double parietal diameter in the two groups were increased when compared with those before treatment，differences being significant (P＜0.05)；the above indexes in the treatment group were higher than those in the control group， differences being significant (P＜0.05). The levels of Ang- Ⅰ ， Ang- Ⅱ and Tie2 were increased when compared with those before treatment， differences being significant (P＜0.05). The levels of Ang-Ⅰ，Ang-Ⅱ and Tie2 were higher than those in the control group， differences being significant (P＜0.05). The incidence rates of cesarean section， postpartum hemorrhage and Apgar score ≤7 within 1 minute of birth in the treatment group were lower than those in the control group (P＜0.05). Conclusion： On the basis of conventional therapy， Jianpi Gutuan Prescription has a significant therapeutic effect on the treatment of FGR of spleen-kidney deficiency type，which can not only effectively relieve the symptoms related to the spleen-kidney deficiency of pregnant women， increase placental perfusion，but also significantly increase the growth rate of the fetus.