Abstract： Objective： To observe the effect of Yangxue Qingnao Pills combined with Betahistine on cerebral blood flow velocity and serum paraoxonase-1 (PON-1) levels in migraine patients. Methods： A total of 80 cases of migraine patients were selected as the study subjects and divided into the control group and the study group according to the random number table method， with 40 cases in each group. The control group was treated with Betahistine， and the study group was additionally treated with Yangxue Qingnao Pills based on the treatment of the control group. Both groups were treated for four courses. Clinical effects were compared between the two groups. The changes in clinical symptom improvement， traditional Chinese medicine (TCM) syndrome scores，cerebral hemodynamic index values [anterior cerebral artery (ACA)，basilar artery (BA)，posterior cerebral artery (PCA)，and middle cerebral artery (MCA)]，levels of serum factors [PON-1， oxidized low-density lipoprotein (ox-LDL)， calcitonin gene-related peptide (CGRP)， and brain-derived neurotrophic factor (BDNF)] were compared between the two groups before and after treatment. Results：The total clinical effective rate was 97.50% in the study group and 80.00% in the control group，the difference being significant (P＜0.05). After treatment，the duration of pain，and the frequency and degree of headache attacks in the two groups were decreased when compared with those before treatment (P＜0.05)，and the duration of pain，and the frequency and degree of headache attacks in the study group were shorter and lower than those in the control group (P＜0.05). After treatment， TCM syndrome scores of red eyes， vexation and irascibility， bitter taste in the mouth， and vertigo in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above four TCM syndrome scores in the study group were lower than those in the control group (P＜0.05). After treatment， cerebral hemodynamic index values of ACA，BA，PCA，and MCA in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above four indicators in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of ox-LDL，CGRP，and BDNF in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of PON-1 were increased when compared with those before treatment (P＜0.05)； the levels of ox-LDL， CGRP， and BDNF in the study group were lower than those in the control group (P＜0.05)， and level of PON-1 in the study group was higher than that in the control group (P＜0.05). Conclusion： Yangxue Qingnao Pills combined with Betahistine for migraine patients can relieve their clinical symptoms，improve cerebral blood flow velocity，and enhance serum PON-1 levels.