Abstract：Objective：To observe the clinical effect of fumigation and washing with Qingre Jiedu Zaoshi Prescription on postoperative wound of perianal abscess and its effects on inflammatory factors and related growth factors. Methods： A total of 118 cases of patients with perianal abscess were divided into the control group and the treatment group according to the random number table method， with 59 cases in each group. Both groups were given one-time radical resection of low-position perianal abscess； after operation，the control group was treated with sitz bath with potassium permanganate，and the treatment group was treated with Qingre Jiedu Zaoshi Prescription for fumigation and washing. Both groups were treated for two weeks. Traditional Chinese medicine (TCM) syndrome scores， postoperative wound recovery， inflammatory factors， and related growth factors were compared between the two groups before and after treatment； clinical effects and the incidence of adverse reactions were evaluated in the two groups. Results：After treatment，the total effective rate was 94.92% in the treatment group，higher than that of 83.05% in the control group (P＜0.05)，and the time for slough detachment and wound healing in the treatment group was shorter than that in the control group (P＜0.05). After treatment， the TCM syndrome scores， levels of interleukin-6 (IL-6)， C-reactive protein (CRP)， and tumor necrosis factor- α (TNF-α) in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of fibroblast growth factors (FGF) and vascular endothelial growth factor (VEGF) were increased (P＜ 0.05)；the TCM syndrome scores level of each inflammatory factor in the treatment group was lower than that in the control group (P＜0.05)，and the level of each related growth factor in the treatment group was higher than that in the control group (P＜0.05). No adverse reactions happened in the two groups. Conclusion：Qingre Jiedu Zaoshi Prescription for fumigation and washing can accelerate the postoperative wound healing of patients with perianal abscess， reduce inflammatory reactions， increase the levels of related growth factors，and improve curative effects，with high safety.