Abstract ： Objective ： To observe the curative effect of Xiezhuo Tongluo Pescription on phase 3- 4 chronic kidney disease and its influence on the quality of life of patients. Methods ： A total of 100 patients with phase 3-4 chronic kidney disease were selected and divided into the trial group and the control group according to random number table method，with 50 patients in each group. The two groups were given basic treatment；the trial group was given Xiezhuo Tongluo Pescription，and the control group was given placebo. The treatment course of both groups was 12 weeks. The clinical effects and the effects of traditional Chinese medicine syndromes in the two groups were compared. The changes of laboratory indexes [alanine aminotransferase (ALT)，aspartate aminotransferase (AST)，serum potassium (K+ )，serum creatinine (SCr)，serum cystatin C (CysC)，blood urea nitrogen (BUN)，albumin/urine creatinine ratio (ACR)， urinary protein quantification and estimated glomerular filtration rate (eGF)] and quality of life scores [Physical Component Summary (PCS)，Mental Component Summary (MCS)，Kidney Disease Burden (KDB)，Kidney Disease Effect (KDE)， Disease Related Syndrome (DRS)] were also compared between the two groups before and after treatment. Results：The total effective rate was 80.0% in the trial group and 60.9% in the control group， the difference being significant (P＜0.05). The total effective rate of traditional Chinese medicine syndromes was 88.9% in the trial group and 78.3% in the control group， the difference being significant (P＜0.05). After treatment， the levels of BUN， SCr， CysC， ACR and urinary protein quantification in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of BUN， SCr， CysC， ACR and urinary protein quantification in the trial group were lower than those in the control group (P＜0.05). After treatment， the levels of eGFR in both groups were increased when compared with those before treatment (P＜0.05)，and the eGFR level in the trial group was higher than that in the control group (P＜0.05). After treatment，the scores of PCS，MCS，KDB，KDE and DRS in the trial group were increased when compared with those before treatment (P＜0.05)， and the above five scores were higher than those in the control group (P＜0.05). Conclusion： Xiezhuo Tongluo Granules has a good effect on phase 3-4 chronic kidney disease，and can improve the kidney function and quality of life.