Abstract：Objective：To observe the clinical effect of the therapy of acupoints massage combined with moxibustion for upper limb lymphedema after surgery of breast cancer. Methods：A total of 80 patients with upper limb lymphedema after surgery of breast cancer were divided into the control group and the treatment group according to the random number table method，with 40 cases in each group. The two groups were treated with Diosmin Tablets， the control group was additionally given massage and exercises of upper limbs for treatment， and the treatment group was additionally treated with acupoints massage combined with moxibustion. The two groups were treated for eight weeks. The clinical effects， and the scores of Breast Cancer Lymphedema Symptom Experience Index (BCLE-SEI)， fibrosis grading of lymphedema， Visual Analogue Scale (VAS) of swelling and pain， and Functional Assessment of Cancer Therapy-Breast (FACT-B) and the range of motion of upper limbs were compared before and after treatment between the two groups. Results：After treatment，the total effective rate was 95.00% in the treatment group，higher than that of 80.00% in the control group (P＜0.05). After treatment，scores of BCLE-SEI，fibrosis grading of lymphedema，VAS of swelling and pain and FACT-B dimensions (physiology，society/family，emotion， function and others) in the two groups were decreased when compared with those before treatment (P＜ 0.05). After treatment，the range of motion of elevation，inward and outward rotation，and horizontal flex and extension of upper limb in the two groups were respectively increased (P＜0.05)， and the range of rotation of above five items in the treatment group was higher than that in the control group (P＜0.05). Conclusion：The therapy of acupoints massage combined with moxibustion has a definite curative effect on upper limb lymphedema after surgery of breast cancer，which can mitigate the edema of affected limbs and the pain degree，promote the recovery of function of upper limbs and improve the quality of life.