Abstract：Multiple myeloma (MM) is a common hematologic malignancy in the senile，which seriously endangers the health of patients. Professor ZHU Lingling clinically finds that Tiangui is closely related to the occurrence and development of MM. She considers that MM is usually with deficiency-excess complex， the pathogenesis is based on Tiangui exhausion， liver-kidney deficiency is the root， phlegm， toxin and stasis are the tip， and the combination of the above causes the disease. Professor ZHU advocates the syndrome differentiation and treatment by stages. In the early stage，phlegm and toxin obstruction，and qi stagnation with blood stasis were the main syndromes. Huanglian Jiedu Decoction combined with Shentong Zhuyu Decoction can be used to clear heat and resolve toxins and invigorate blood and dissolve stasis； Xuefu Zhuyu Decoction can be used to invigorate blood and dissolve stasis and rectify qi and relieve pain. In the middle stage，the syndrome of kidney deficiency and blood stasis is the main one，and Duhuo Jisheng Decoction can be used to supplement kidney and invigorate blood. In the late stage， the liver-kidney yin deficiency syndrome， spleen-kidney yang deficiency syndrome and qi-blood deficiency syndrome are main ones. Liuwei Dihuang Pills combined with Shaoyao Gancao Tang can be used to boost kidney and replenish essence and soften liver and relieve pain；Fuzi Lizhong Pills or Shenqi Pills combined with Sijunzi Decoction can be used to warm the center and dissipate cold，supplement and boost spleen and kidney； Bazhen Decoction can be used to boost qi and fortify the spleen and supplement and invigorate blood. At the same time，Professor ZHU stresses that the clinical treatment should integrate both Chinese and western medicine to achieve the purpose of enhancing efficiency and reducing toxin，improving the quality of life of patients，reducing disease recurrence and extending the life cycle.