Abstract： Objective： To observe the effect of Shirun Shaoshang Ointment combined with Mupirocin Ointment on wound healing and scar morphology in patients with extremities second-degree burns. Methods：A total of 94 cases of patients with extremities second-degree burns were selected and divided into the observation group and the control group by random number table method，with 47 cases in each group. One case was respectively excluded in both groups during treatment，and 46 cases were included in the study eventually. The control group was treated with Mupirocin Ointment， and the observation group was additionally treated with Mupirocin Ointment based on the treatment of the control group. Both groups were treated for 30 days. The clinical effects， pain degree assessed by Visual Analogue Scale (VAS)， wound healing time， wound blood circulation recovery time and scar repair assessed by Vancouver Scar Scale (VSS) were compared between the two groups. Results： After 30 days of treatment， the Grade I healing rate in the observation group was 95.65%， higher than that of 80.43% in the control group， the difference being significant (P＜0.05). After 7，15 and 30 days of treatment，the VAS scores in both groups were decreased gradually， and the VAS scores in the observation group were lower than those in the control group at the same period， differences being significant (P＜0.05). The wound healing time and wound blood circulation recovery time in the observation group were shorter than those in the control group， differences being significant (P＜0.05). After 30 days of treatment， the scores of thickness， softness， color and vascular distribution in the observation group were lower than those in the control group， differences being significant (P＜0.05). Conclusion：Shirun Shaoshang Ointment combined with Mupirocin Ointment has a significant therapeutic effect on the treatment of extremities second-degree burns，which can promote pain relief and wound blood flow recovery， enhance the healing rate of Grade I wound and improve scar morphology.