温阳化饮汤联合调制中频电疗法治疗多囊卵巢综合征高雄激素血症临床研究
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R711.75

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浙江康复医疗中心院级科研课题(ZK2007)


Clinical Study on Wenyang Huayin Decoction Combined with Modulated Medium Frequency Electrotherapy for Polycystic Ovary Syndrome with Hyperandrogenism
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    摘要:

    目的:观察温阳化饮汤联合调制中频电疗法治疗多囊卵巢综合征高雄激素血症(PCOS-HA) 的临 床疗效。方法:采用EXCEL软件生成对应随机数字并以1∶1∶1的比例,将纳入观察的60例PCOS-HA患者分 为温阳化饮汤组、温阳化饮汤联合调制中频电治疗组(联合组)、西药组各20例。西药组予炔雌醇环丙孕酮片 治疗,温阳化饮汤组予温阳化饮汤治疗,联合组予温阳化饮汤联合调制中频电治疗,3组均连续治疗6个月经 周期。评估各组治疗前后月经周期变化、睾酮(T)、促黄体生成素(LH)、促卵泡刺激素(FSH)、Ferrimnan- Gallway(F-G) 评分、痤疮Rosefiled评分并进行比较。结果:治疗3个月,调经总有效率温阳化饮汤组35.0%, 联合组45.0%,西药组85.0%;治疗6个月,调经总有效率温阳化饮汤组65.0%,联合组75.0%,西药组90.0%; 治疗结束后3个月随访时,调经总有效率温阳化饮汤组50.0%,联合组70.0%,西药组30.0%。治疗结束后, 3 组T、LH/FSH、F-G评分、Rosefiled评分均较治疗前下降,差异均有统计学意义(P<0.05)。治疗结束后, 3组组间T、LH/FSH、F-G评分比较,差异均无统计学意义(P>0.05)。治疗结束后,3组间Rosefiled评分比 较,差异有统计学意义(P<0.05);组间两两比较,温阳化饮汤组、联合组Rosefiled 评分差异无统计学意 义(P>0.05),2组Rosefiled评分均低于西药组(P<0.05)。结论:温阳化饮汤、温阳化饮汤联合调制中频电 治疗PCOS-HA均能调整生殖激素水平,改善临床症状,且联合治疗相较于西药炔雌醇环丙孕酮片,具有更好 的远期疗效。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Wenyang Huayin Decoction combined with modulated medium frequency electrotherapy on polycystic ovary syndrome with hyperandrogenism (PCOSHA). Methods:EXCEL software was used to generate corresponding random numbers and at the ratio of 1∶ 1∶1,60 patients with PCOS-HA were divided into the Wenyang Huayin Decoction group,the Wenyang Huayin Decoction combined with modulated medium frequency electrotherapy group (the combination group) and the western medicine group with 20 cases in each group. The western medicine group was treated with Ethinylestradiol and Cyproterone Acetate Tablets;the Wenyang Huayin Decoction group was treated with Wenyang Huayin Decoction, and the combination group was treated with Wenyang Huayin Decoction combined with modulated medium frequency electrotherapy. The three groups were treated for six menstrual cycles continuously. The changes of menstrual cycle,testosterone (T),luteinizing hormone (LH),follicle stimulating hormone (FSH),scores of Ferriman-Gallway (F-G),and score of acne Rosefiled were evaluated and compared before and after treatment. Results:After three months of treatment,the total effective rate of menstruation regulation was 35.0% in the Wenyang Huayin Decoction group,45.0% in the combination group,and 85.0% in the western medicine group. After six months of treatment,the total effective rate of menstruation regulation was 65.0% in the Wenyang Huayin Decoction group,75.0% in the combination group, and 90.0% in the western medicine group; after three months of follow-up, the total effective rate of menstruation regulation was 50.0% in the Wenyang Huayin Decoction group, 70.0% in the combination group, and 30.0% in the western medicine group. After the end of treatment, the levels of T,LH/FSH,scores of F-G and Rosefiled in the three groups were decreased when compared with those before treatment,differences being significant (P<0.05). After the end of treatment,there was no significant difference in the levels of T, LH/FSH, and F-G score between the three groups (P>0.05). After the end of treatment, there was significant difference in Rosefiled score between the three groups (P<0.05);there was no significant difference in Rosefiled score between the Wenyang Huayin Decoction group and the combination group (P>0.05), and the Rosefiled scores in the two groups were lower than those in the western medicine group (P<0.05). Conclusion:Wenyang Huayin Decoction and the therapy of Wenyang Huayin Decoction combined with modulated medium frequency electrotherapy for PCOS-HA can adjust the reproductive hormone levels and improve clinical symptoms, and the combined treatment has better long-term effect than Ethinylestradiol and Cyproterone Acetate Tablets.

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赵林叶,王静,陈勤,李辉,俞红.温阳化饮汤联合调制中频电疗法治疗多囊卵巢综合征高雄激素血症临床研究[J].新中医,2024,56(12):92-98

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  • 在线发布日期: 2024-06-28
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