Abstract： Objective： To observe the therapeutic effect of hot compress with Fuke Zhuyu Wenjing Package and Levofloxacin Hydrochloride Tablets on chronic pelvic inflammatory disease of cold-damp stagnation type. Methods： A retrospective analysis was conducted on the clinical data of 96 patients with chronic pelvic inflammatory disease of cold-damp stagnation type. According to different treatment methods，they were divided into the observation group and the control group，with 48 cases in each group. The control group was treated with Levofloxacin Hydrochloride Tablets，the observation group was treated with hot compress with Fuke Zhuyu Wenjing Package combined with Levofloxacin Hydrochloride Tablets. Both groups were treated for two treatment courses， 14 days being a course. The traditional Chinese medicine (TCM) syndrome scores were evaluated before and after treatment， and inflammatory factors indicators [interleukin-1β (IL-1β)， tumor necrosis factor- α (TNF- α)， C-reactive protein (CRP)] and hemorheological indicators [plasma viscosity (PV)，hematocrit (PCV)，erythrocyte sedimentation rate (ESR)] were detected. The clinical effects and the incidences of adverse reactions in the two groups were compared. Results：After two courses of treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). The TCM syndrome scores in both groups were decreased when compared with those before treatment (P＜0.05). The TCM syndrome scores in the observation group was lower than that in the control group (P＜0.05). The levels of IL-1β，TNF-α and CRP in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of IL-1β，TNF- α and CRP in the observation group were lower than those in the control group (P＜0.05). The PV，PCV，and ESR levels in both groups were decreased when compared with those before treatment (P＜0.05)；the PV， PCV，and ESR levels in the observation group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： The application of Fuke Zhuyu Wenjing Package and Levofloxacin Hydrochloride Tablets can improve the clinical effect on the treatment of chronic pelvic inflammatory disease of cold-damp stagnation type， which can more effectively alleviate clinical symptoms， alleviate inflammatory reactions， promote blood circulation than the single use of Levofloxacin Hydrochloride Tablets.