Abstract： Objective： To observe the clinical effect of the therapy of Quyu Shengxin Acupuncture Method combined with acupoint application with Evodia Rutaecarpa on insomnia after cerebral hemorrhage. Methods： A total of 93 patients with insomnia after cerebral hemorrhage were selected as the study subjects and divided into the control group and the observation group according to the random number table method，with 46 and 47 cases in each group. The control group was treated with routine western medicine and Zolpidem Tartrate， and the observation group was additionally treated with Quyu Shengxin Acupuncture Method combined with acupoint application with Evodia Rutaecarpa based on the treatment of the control group. The clinical effects and incidence of adverse reactions after one month of treatment，the traditional Chinese medicine (TCM)syndrome scores，the scores of Pittsburgh Sleep Quality Index (PSQI)， Karnofsky Performance Scale (KPS) and Irritable Bowel Syndrome-Quality of Life (IBS-QOL) and the levels of blood biochemistry indexes [hematocrit (HCT)，angiotensin-converting enzyme (ACE)，Cystatin C (CysC) and homocysteine (Hcy)] before and after treatment were respectively compared between the two groups. Results：After treatment，the total effective rate was 95.74% in the observation group and 80.43% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of chronic insomnia， chest distress， sleep restlessness and thoracodynia or chronic headache and the total scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the PSQI scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the PSQI score in the observation group was lower than that in the control group (P＜0.05). After treatment，the scores of KPS and IBS-QOL in the two groups were increased when compared with those before treatment (P＜0.05)，and the above two scores in the observation group were higher than those in the control group (P＜0.05). After treatment， the levels of HCT， ACE， CysC and Hcy in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four levels of blood biochemistry indexes in the observation group were lower than those in the control group (P＜0.05). There was no adverse reaction in the two groups during treatment. Conclusion： The therapy of Quyu Shengxin Acupuncture Method combined with acupoint application with Evodia Rutaecarpa has a significant clinical effect on insomnia after cerebral hemorrhage， which can effectively improve the TCM syndrome， sleep quality and oxidative stress level and enhance the quality of life.