Abstract: This paper introduces the clinical experience of the veteran doctors of traditional Chinese medicine, FENG Wuji, in treating depression from the perspective of cold-damp. FENG believes that depression focuses on the performance of mental disorders, accompanied by fear of cold, white and greasy coating and other symptoms, and there are obvious characteristics of spleen-kidney yang deficiency, and cold-damp obstruction and stagnation. Therefore, he proposes to treat from the colddamp theory, and take warming yang and dissipating cold as well as eliminating dampness and resolving constraint as the treatment methods.