Abstract：Objective：To observe the clinical effect of Chaihu Shugan San combined with Taohong Siwu Decoction on postherpetic neuralgia (PHN). Methods：A total of 140 PHN patients of qi stagnation and blood stasis type were selected and divided into the control group and the observation group according to random number table method，with 70 cases in each group. The control group was orally treated with Gabapentin Capsules，and the observation group was additionally treated with Taohong Siwu Decoction combined with Chaihu Shugan San based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects and incidence of adverse reactions were compared between the two groups. The changes of Visual Analogue Scale of pain (VAS)， Dermatology Life Quality Index (DLQI)， serum neuropeptide Y (NPY)， Substance P (SP)， β-endorphin (β-EP)， central nerve specific egg (S100β) and neuron-specific enolase (NSE) were compared between the two groups before and after treatment. Results：After four weeks of treatment，the total effective rate was 91.43% in the observation group and 74.28% in the control group，the difference being significant (P＜0.05). After four weeks of treatment，the scores of VAS and DLQI in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of VAS and DLQI in the observation group were lower than those in the control group (P＜0.05). After treatment， the serum NPY and SP levels in the two groups were decreased when compared with those before treatment， and the β-EP levels were increased when compared with those before treatment (P＜0.05)； the levels of NPY and SP in the observation group were lower than control group (P＜0.05)， and the level of β-EP was higher than the control group (P＜0.05). After four weeks of treatment， the levels of serum S100β and NSE in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of serum S100β and NSE in the observation group were lower than the control group (P＜0.05). The incidence of adverse reactions was 8.57% in the observation group and 7.14% in the control group， there being no significant difference between the two groups (P> 0.05). Conclusion： The therapy of Chaihu Shugan San combined with Taohong Siwu Decoction can effectively improve nerve immune function，inhibit nerve injury，relieve pain and improve quality of life of PHN patients.