Abstract：Objective：To observe the effect of the therapy of Wenfei Decoction combined with western medicine on pulmonary ciliary movement，airway hyperresponsiveness and balance of T helper cell (Th17) / regulatory cell (Treg) of patients with refractory bacterial infection complicated with acute exacerbation of chronic pulmonary heart disease (AECOPD). Methods： A total of 94 AECOPD patients with refractory bacterial infection were selected and divided into the Chinese medicine group and the routine group according to the random number table method，with 47 cases in each group. The routine group was given symptomatic treatment with routine western medicine， and the Chinese medicine group was additionally treated with Wenfei Decoction based on the treatment of the routine group. The two groups were treated for 14 days. The clinical effects and incidence of adverse reactions， and the changes of lung function indexes [forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC)， partial pressure of oxygen in arterial blood (PaO2) and mucociliary clearance time (MCT)]， airway responsiveness indexes [superoxide dismutase (SOD)，glutathione peroxidase (GSH-Px) and malondialdehyde (MDA)] and immune function indexes [Th17/Treg，interleukin-17 (IL-17)，and transforming growth factor- β1 (TGF- β1)] were compared before and after treatment between the two groups. Results：The total clinical effective rate was 95.75% in the Chinese medicine group，and 82.98% in the routine group，the difference being significant (P＜0.05). After treatment， the levels of FEV1/FVC and PaO2 in the two groups were increased when compared with those before treatment (P＜0.05)， the MCT levels were reduced when compared with those before treatment (P＜0.05)； the levels of FEV1/FVC and PaO2 in the Chinese medicine group were higher than those in the routine group (P＜0.05)，and the MCT was less than that in the routine group (P＜ 0.05). After treatment，the levels of SOD and GSH-Px in the two groups were increased when compared with those before treatment (P＜0.05)， and the MDA levels were decreased when compared with those before treatment (P＜0.05)； the levels of SOD and GSH-Px in the Chinese medicine group were higher than those in the routine group (P＜0.05)，and the MDA level was lower than that in the routine group (P＜ 0.05). After treatment， the levels of Th17/Treg， IL-17 and TGF- β1 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the Chinese medicine group were lower than those in the routine group (P＜0.05). During treatment， the incidence of adverse reactions was 10.64% in the Chinese medicine group and 8.51% in the routine group， there being no significance in the difference (P＞0.05). Conclusion： The therapy of Wenfei Decoction combined with western medicine has a significant curative effect on AECOPD patients with refractory bacterial infection， which can enhance the pulmonary ciliary movement，decrease the airway hyperresponsiveness，regulate the immune function，reduce the airway injuries and improve the lung function with great safety.