中药降脂茶联合阿托伐他汀钙片治疗高脂血症临床研究
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Clinical Study on Chinese Herbal Lipid-Lowering Tea Combined with Atorvastatin Calcium Tablets for Hyperlipidemia
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    摘要:

    目的:观察中药降脂茶联合阿托伐他汀钙片治疗高脂血症的临床疗效。方法:选取120例高脂血 症患者,按随机数字表法分为研究组与对照组各60例。对照组给予口服阿托伐他汀钙片治疗,研究组在对照 组基础上联合中药降脂茶治疗。比较2组临床疗效及不良反应发生情况,比较2组治疗前后血脂水平[甘油三 酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C) ]、中医证候 积分、血液流变学参数值[全血比黏度(WBV)、血浆比黏度(PV)、全血还原黏度(WBRV)、血细胞比 容(HCT) ]的变化。结果:治疗后,研究组临床总有效率为95.00%,对照组为80.00%,2组比较,差异有统 计学意义(P<0.05)。治疗后,2组TC、TG、LDL-C水平均较治疗前下降(P<0.05),HDL-C水平均较治疗 前上升(P<0.05);研究组TC、TG、LDL-C 水平均低于对照组(P<0.05),HDL-C 水平高于对照组(P< 0.05)。治疗后,2组中医证候主症、次症及总分均较治疗前下降(P<0.05),研究组主症、次症及总分均低于 对照组(P<0.05)。治疗后,2组WBV、PV、WBRV、HCT指标值均较治疗前下降(P<0.05),研究组WBV、 PV、WBRV、HCT指标值均低于对照组(P<0.05)。研究组不良反应发生率为21.67%, 对照组为18.33%, 2 组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:中药降脂茶联合阿托伐他汀钙片治疗高脂血 症的疗效确切,有利于改善血脂水平及血液高凝状态。

    Abstract:

    Abstract:Objective:To observe the clinical effect of the therapy of Chinese herbal lipid-lowering tea combined with Atorvastatin Calcium Tablets on hyperlipidemia. Methods: A total of 120 patients with hyperlipidemia were selected and divided into the study group and the control group according to the random number table method,with 60 cases in each group. The control group was given oral administration of Atorvastatin Calcium Tablets, and the study group was additionally treated with Chinese herbal lipidlowering tea based on the treatment of the control group. The clinical effects and incidence of adverse reactions,and the changes of levels of blood lipid indexes [triglyceride (TG),total cholesterol (TC),highdensity lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)], traditional Chinese medicine syndrome scores, hemorheology parameters [plasma viscosity (PV), whole blood viscosity (WBV),whole blood reduced viscosity (WBRV) and hematocrit (HCT)] were compared before and after treatment between the two groups. Results: After treatment, the total clinical effective rate was 95.00% in the study group and 80.00% in the control group,the difference being significant (P<0.05). After treatment,the levels of TC,TG and LDL-C in the two groups were decreased when compared with those before treatment (P<0.05), and the HDL-C levels were increased when compared with those before treatment (P<0.05); the levels of TC, TG and LDL-C in the study group were lower than those in the control group (P<0.05), and the HDL-C level was higher than that in the control group (P<0.05). After treatment,the traditional Chinese medicine syndrome scores of primary symptoms,secondary symptoms and total scores in the two groups were decreased when compared with those before treatment (P<0.05), and the above three scores in the study group were lower than those in the control group (P<0.05). After treatment,the values of WBV,PV,WBRV and HCT in the two groups were decreased when compared with those before treatment (P<0.05),and the above four values in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions was 21.67% in the study group and 18.33% in the control group, there being no significance in the difference (P>0.05). Conclusion: The therapy of Chinese herbal lipid-lowering tea combined with Atorvastatin Calcium Tablets has a definite curative effect on hyperlipidemia,which can improve the level of blood lipid and the hypercoagulation state.

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郭婷婷,李跃文.中药降脂茶联合阿托伐他汀钙片治疗高脂血症临床研究[J].新中医,2024,56(13):97-101

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  • 在线发布日期: 2024-07-10
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