Abstract： Objective： To observe the curative effect of modified Xiaoke Prescription combined with intensive therapy with short-term insulin pump for incipience patients with type 2 diabetes mellitus. Methods： A total of 100 cases of incipience patients with type 2 diabetes mellitus were selected and divided into the control group and the observation group according to different treatment，with 50 cases in each group. The control group received intensive therapy with short-term insulin pump， and the observation group received additional treatment with Xiaoke Prescription based on the treatment of the control group. The clinical effects and incidence of adverse reactions were compared between the two groups. The changes in traditional Chinese medicine (TCM) syndrome scores，fasting blood glucose (FBG)， homeostasis model assessment of β-cell function (HOMA- β)， and blood glucose fluctuation parameters [mean amplitude of glycemic excursions (MAGE) and standard deviation of mean blood glucose (SDBG)] were compared before and after treatment between the two groups. Results： The effective rate was 96.00% in the observation group， and 78.00% in the control group， the difference being significant (P＜ 0.05). After treatment，the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the FBG levels in the two groups were decreased when compared with those before treatment (P＜0.05)， HOMA- β were increased when compared with those before treatment (P＜0.05)；the FBG level in the observation group was lower than that in the control group (P＜0.05)， HOMA- β were higher than that in the control group (P＜0.05). After treatment， the blood glucose fluctuation parameters including MAGE and SDBG in the two groups were decreased when compared with those before treatment (P＜0.05)，and the MAGE and SDBG in the observation group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 2.00% in the observation group， and 10.00% in the control group， and there was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Modified Xiaoke Prescription combined with short-term intensive insulin therapy has a good effect in treating type 2 diabetes mellitus，which can improve symptoms，lower blood sugar levels，improve islet function，and has strong stability and high safety.