Abstract：Objective：To observe the clinical effect of the therapy of Shire Yong'e Decoction combined with Moxifloxacin Hydrochloride Tablets on acute pelvic inflammatory disease (APID) with excessive dampness toxin syndrome. Methods： A total of 84 APID patients were divided into the control group and the observation group according to the random number table method， with 42 cases in each group. The control group was given oral administration of Moxifloxacin Hydrochloride Tablets， and the observation group was additionally treated with Shire Yong'e Decoction based on the treatment of the control group. The two groups were treated for two weeks. The clinical effects in the two groups were evaluated； the traditional Chinese medicine syndrome scores and levels of serum inflammation markers， hemorheology indexes and immune indexes were compared before and after treatment between the two groups； the incidence of adverse reactions was observed. Results： The total effective rate was 92.86% in the observation group， higher than that of 78.57% in the control group， the difference being significant (P＜ 0.05). After treatment， the traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above score in the observation group was lower than that in the control group (P＜0.05). After treatment，the levels of serum C-reactive protein (CRP)，interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of CRP， IL-8 and TNF- α in the observation group were lower than those in the control group (P＜0.05). After treatment， the high-shear whole blood viscosity， low-shear whole blood viscosity and blood viscosity in the two groups were decreased when compared with those before treatment (P＜0.05)， and the high-shear whole blood viscosity， low-shear whole blood viscosity and blood viscosity in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of CD3+，CD4+ and CD4+/CD8+ in the two groups were increased when compared with those before treatment (P＜0.05)，and the CD8+ levels were decreased when compared with those before treatment (P＜0.05)； the levels of CD3+ ， CD4+ and CD4+/ CD8+ in the observation group were higher than those in the control group (P＜0.05)， and the CD8+ level was lower than that in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Shire Yong'e Decoction combined with Moxifloxacin Hydrochloride Tablets can effectively improve the clinical symptoms and hemorheology indexes of APID patients with excessive dampness toxin syndrome， mitigate the inflammatory responses and enhance the immunity.