Abstract：Objective：To explore the medication rules of national patented Chinese herbal compounds for ankylosing spondylitis based on data mining. Methods： The patent database of the China National Intellectual Property Administration of the People's Republic of China was used to screen the national patent Chinese herbal compounds for ankylosing spondylitis. Excel， R4.3.1， Cytoscape3.9.1 and other software were applied to carry out data mining by methods of frequency analyse， nature and taste meridian orientation， association rules， complex networks and so on. Results： A total of 275 national patented Chinese herbal compounds were included， involving 411 types of Chinese herbal medicine， with a total frequency of 4 115 times. High-frequency Chinese herbal medicine for ankylosing spondylitis included Achyranthis Bidentatae Radix， Angelicae Sinensis Radix， Glycyrrhizae Radix et Rhizoma， etc. Medicinals for supplementing deficiency， dispelling wind and dampness， and promoting blood circulation and removing blood stasis were commonly used. The medicinal properties were mostly warm， and the medicinal flavors were mostly bitter，spicy，and sweet，mostly attributed to the liver meridian. Based on the association rules，34 drug combinations were obtained，including Olibanum-Myrrha，Astragali Radix- Angelicae Sinensis Radix， and Eucommiae Cortex-Achyranthis Bidentatae Radix. Cluster analysis was conducted on the six new prescriptions，including Cibotii Rhizoma-Eucommiae Cortex-Glycyrrhizae Radix et Rhizoma，and Rhizoma Chuanxiong-Paeoniae Radix Alba-Rehmanniae Radix Praeparata. Factor analysis revealed seven factor combinations， including Chuanxiong Rhizoma-Olibanum-Myrrha-Carthami Flos， and Cinnamomi Ramulus-Saposhnikoviae Radix-Asari Radix et Rhizoma. Complex network discovered that core drug combinations included formulas such as Bushen Qiangdu Zhilou Decoction，and Duhuo Jisheng Decoction. Conclusion： The national patented Chinese herbal compounds are commonly used to treat ankylosing spondylitis with medicinals such as Achyranthis Bidentatae Radix， Angelicae Sinensis Radix， and Glycyrrhizae Radix et Rhizoma. The commonly used treatment methods include supplementing deficiency， dispelling wind and dampness， promoting blood circulation and removing blood stasis. In clinical practice， the modified formulas of Bushen Qiangdu Zhilou Decoction， Duhuo Jisheng Decoction， and Danggui Buxue Decoction are often used for syndrome differentiation and treatment，with adjustments made according to the symptoms.