Abstract：Objective：To discuss the medication characteristics and prescription rules of Director ZHOU Jihong treating patients who received surgery of pulmonary nodules with traditional Chinese medicines. Methods：Prescriptions of 342 patients receiving surgery of pulmonary nodules were collected to establish a database. SPSS Modeler 18.0 and SPSS Statistics 24.0 were used to perform frequency statistics for Chinese medicines used in the prescriptions，association rule analysis and hierarchical cluster. Results：A total of 372 prescriptions were included， involving 194 Chinese medicines. A total of 11 were used more than 150 times (use frequency ≥ 40%)， including Glycyrrhizae Radix et Rhizoma Praeparata cum Melle， Poria， Atractylodis Macrocephalae Rhizoma Stir-fried with Bran， Angelicae Sinensis Radix， Astragali Radix， Platycodonis Radix， Pinelliae Praeparatum Rhizoma， Citri Reticulatae Pericarpium， Ophiopogonis Radix，Paeoniae Alba Radix and Rehmanniae Radix. Among the highly-used Chinese medicines，those for channel entries to the spleen and stomach accounted for the most ， up to 22 (77.3%) ； followed by 18 (60.0%) for channel entries to the lung and large intestine；those for channel entries to the kidney were the least， with only 4 (13.3%). The association rule analysis (support ≥ 10%， confidence level ≥ 85%， maximum number of antecedent 1) suggested 71 association rules， and the combinations of Glycyrrhizae Radix et Rhizoma Praeparata cum Melle and Poria， Atractylodis Macrocephalae Rhizoma Stir-fried with Bran and Astragali Radix， Poria and Pinelliae Praeparatum Rhizoma， Glycyrrhizae Radix et Rhizoma and Angelicae Sinensis Radix were all commonly used for the treatment of pulmonary nodules after surgery. The cluster analysis presented seven combinations， and the first group was mainly for regulating qi and dissolving phlegm， including Bambusae Caulis in Taenia， Atractylodis Macrocephalae Rhizoma Stir-fried with Aurantii Fructus Immaturus and Jujubae Fructus；the second group was mainly for activating blood and dispelling stasis， including Chuanxiong Rhizoma processed by yellow wine and blazing Persicae Semen； the third group had only Glycyrrhizae Radix et Rhizoma Praeparata cum Melle with main effect of dispelling phlegm and suppressing cough， and harmonizing each Chinese medicine； the fourth group had only Sclerotium Poriae Pararadicis，mainly for calming the mind and tranquilizing；the fifth group was mainly for boosting qi and securing the exterior，including Atractylodis Macrocephalae Rhizoma Stir-fried with Bran， Astragali Radix and Saposhnikoviae Radix； the sixth group was mainly for fortifying the spleen and nourishing the stomach， clearing heat and dissipating binds， and fortifying the spleen and draining dampness， including Gigeriae Galli Endothelium Corneum Preparata， Hordei Fructus Germinatus and Pseudostellariae Radix；the seventh group was mainly for nourishing the lung and kidney，and suppressing cough and dissolving phlegm，including Lilii Bulbus，Scrophulariae Radix and Fritillariae Thunbergii Bulbus. Conclusion：The basic treatment principles of patients undergoing surgery of pulmonary nodules should be nourishing the kidney and tonifying the lung，boosting qi and securing the exterior，moving qi and resolving phlegm，activating and tonifying blood，and one of the medication characteristics is treating lung diseases from the spleen and stomach.