Abstract：Objective：To observe the clinical effect of modified Banxia Xiexin Decoction combined with quadruple chemotherapy on chronic gastritis (CG) with cold-heat complex syndrome and its effect on pepsin. Methods：The clinical data of 80 cases of patients with CG with cold-heat complex syndrome were collected and divided into the control group and the observation group according to the random number table method， with 44 and 36 cases in each group respectively. The control group was treated with routine quadruple chemotherapy，and the observation group was additionally treated with Banxia Xiexin Decoction based on the treatment of the control group. After treatment， the changes in clinical effects， traditional Chinese medicine (TCM) syndrome scores and levels of pepsin indexes [pepsinogen Ⅰ (PG Ⅰ) and pepsinogen Ⅱ (PG Ⅱ)] were compared between the two groups. Results： The total effective rate was 97.22% in the observation group and 81.82% in the control group， the difference being significant (P＜ 0.05).Before treatment，there was no significant difference being found in the comparison of the scores of stomach duct pain， distension and discomfort， belching， dry mouth and bitter mouth between the two groups (P＞0.05). After treatment，all the above TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and all the scores in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of PG- Ⅰ and PG- Ⅱ between the two groups (P＞0.05). After treatment，the levels of PG-Ⅰand PG-Ⅱin the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of PG-Ⅰand PG-Ⅱin the observation group were lower than those in the control group (P＜0.05). After treatment，the negative conversion rate of Helicobacter pylori in the observation group was 88.89% and 72.73% in the control group，the intergroup of comparison showed that there being no significance in the difference (P＞0.05). Conclusion： Modified Banxia Xiexin Decoction combined with quadruple chemotherapy has a definite curative effect in the treatment of CG with cold-heat complex syndrome，which can effectively improve the TCM syndromes of patients，reduce the levels of pepsin，and promote the repair of gastric mucosa.