Abstract： Objective： To observe the clinical effect of Bushen Huoxue Decoction combined with Levosimendan on chronic heart failure (CHF) of kidney deficiency and blood stasis type and its effects on levels of serum N-terminal pro B-type natriuretic peptide (Nt-proBNP). Methods： A total of 82 cases of CHF patients of kidney deficiency and blood stasis type were divided into the treatment group and the control group according to the random number table method， with 41 cases in each group. The control group was treated with Levosimendan Injection， and the treatment group was additionally treated with self-made Bushen Huoxue Decoction based on the treatment of the control group. Traditional Chinese medicine (TCM) syndrome scores，heart function indicators [left ventricular ejection fraction (LVEF)，stroke volume (SV)， and 6-minute walking distance (6MWD)]， Nt-proBNP， and hypersensitivity C-reactive protein (hs-CRP)] were compared between the two groups before and after treatment. Total effective rates and adverse reactions were counted. Results：The total effective rate was 97.56% in the treatment group and 80.49% in the control group， the difference being significant (P＜0.05). After treatment， TCM syndrome scores of palpitations and shortness of breath，fatigue and lack of strength，chest tightness and pain，soreness and weakness in the waist and knees，vexing heat in the chest，palms and soles，and fear of cold and cold limbs in the two groups were decreased when compared with those before treatment (P＜ 0.05)， and each score in the treatment group was lower than that in the control group (P＜0.05). After treatment， the levels of LVEF， SV， and 6MWD in the two groups were increased when compared with those before treatment (P＜0.05)，and the above three indicators in the treatment group were higher than those in the control group (P＜0.05). After treatment，the levels of Nt-proBNP and hs-CRP in serum in the two groups were declined when compared with those before treatment (P＜0.05)， and the levels of NtproBNP and hs-CRP in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 4.88% in the treatment group and 19.51% in the control group， the difference being significant (P＜0.05). Conclusion： Bushen Huoxue Decoction combined with Levosimendan has significant curative effects on the treatment of CHF of kidney deficiency and blood stasis type，which can improve TCM syndrome scores and heart function of patients，slow down the progression of CHF with fewer adverse reactions.