Abstract： Objective： To observe the clinical effect of Wenyang Tongluo Decoction combined with ZEPUmed intelligent exercise training system for spastic hemiplegia after stroke (SHAS). Methods：A total of 86 cases of patients with SHAS were selected and divided into two groups according to the random number table method. The control group was given routine treatment， basic rehabilitation training and ZEPUmed intelligent exercise training system in rehabilitation medicine department， and the study group was additionally treated with Wenyang Tongluo Decoction based on the treatment of the control group. Clinical effects， traditional Chinese medicine(TCM) syndrome scores， modified Ashworth grading， Fugl- Meyer motor function (FMA)， lower limb joint motion angle， and levels of serum neurotransmitters [glutamic acid (Glu) and γ-aminobutyric acid (GABA)] were compared between the two groups. Results： The total effective rate was 90.70% in the study group and 72.09% in the control group， the difference being significant (P＜0.05). After treatment， TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the study group were lower than those in the control group (P＜0.05). The improvement of modified Ashworth grading in the two groups was better than that before treatment (P＜0.05)， and the improvement of modified Ashworth grading in the study group was better than that in the control group (P＜0.05). FMA scores of lower limbs， hip flexion angle， knee flexion angle and ankle dorsiflexion angle in the two groups were increased when compared with those before treatment (P＜0.05)， and the above indexes in the study group were higher than those in the control group (P＜0.05). After treatment，GABA levels in the two groups were higher than those before treatment (P＜0.05)， and Glu levels were lower than those before treatment (P＜0.05)； the level of GABA in the study group was higher than that in the control group (P＜0.05)，and the level of Glu in the study group was lower than that in the control group (P＜0.05). Conclusion：The application of Wenyang Tongluo Decoction combined with ZEPUmed intelligent exercise training system for SHAS has positive significance in improving the lower limb motor function and joint motion of patients， and can reduce the muscle tension of affected limb and effectively improve the level of neurotransmitters.