Abstract：Objective：To observe the clinical effect of thunder-fire moxibustion on chronic heart failure of yang deficiency and water diffusion type. Methods： A total of 102 cases of patients with chronic heart failure of yang deficiency and water diffusion type were selected and divided into the routine treatment group and the thunder-fire moxibustion group according to the random number table method ， with 51 cases in each group. One case was excluded from each group， and 50 cases were included in each group ultimately. The routine treatment group received western medicine treatment，and the thunder-fire moxibustion group received thunder-fire moxibustion based on the treatment of the routine treatment group. The clinical effects， traditional Chinese medicine (TCM) syndrome scores， 6-minute walking test (6MWT) distance，Minnesota Living with Heart Failure Questionnaire (MLHFQ) scores，and levels of heart and kidney function indicators were compared between the two groups. The adverse reactions were recorded. Results： After treatment， the clinical effect in the thunder-fire moxibustion group was better than that in the routine treatment group (P＜0.05). The TCM syndrome scores and MLHFQ scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score and MLHFQ score in the thunder-fire moxibustion group were lower than those in the routine treatment group (P＜0.05). The 6MWT distance in the two groups were increased when compared with those before treatment (P ＜ 0.05) ， and the 6MWT distance in the thunder-fire moxibustion group was greater than that in the routine treatment group (P＜0.05). The levels of soluble ST2 (sST2)， phosphoinositide 3-kinase (PI3K)，chromogranin A (CgA)，free fatty acid (FFA) and serum creatinine (SCr)， and the values of myocardial energy expenditure (MEE) and left ventricle circumferential end-systolic wall stress (cESS) in the two groups were decreased when compared with those before treatment (P＜0.05) ， and the levels of sST2， PI3K， CgA， FFA and SCr， and the values of MEE and left ventricle cESS in the thunder-fire moxibustion group were lower than those in the routine treatment group (P＜0.05). The left ventricular ejection fraction (LVEF)，peak systolic strain rate (SRs)，early diastolic peak strain rate (SRc) and late diastolic peak strain rate (SRa) of the right ventricle， and glomerular filtration rate (GFR) in the two groups were increased when compared with those before treatment (P＜0.05)， and LVEF， SRs， SRc， SRa of the right ventricle， and GFR in the thunder-fire moxibustion group were higher than those in the routine treatment group (P＜0.05). The left ventricular mass index (LVMI) and left ventricular end systolic diameter (LVESd) in the two groups were decreased when compared with those before treatment (P＜0.05)， and the LVMI and LVESd in the thunder-fire moxibustion group were lower than those in the routine treatment group (P＜0.05). During the treatment period，neither group experienced any adverse reactions. Conclusion：Thunder-fire moxibustion for chronic heart failure of yang deficiency and water diffusion type can regulate the levels of sST2， PI3K， CgA， FFA and other indicators， improve clinical symptoms and cardiac and renal outcomes， slow down ventricular remodeling， and enhance activity endurance and quality of life.