Abstract： Objective： To observe the effect of the therapy of acupoint catgut embedment combined with rehabilitation training on the upper limb function and activity of daily living of patients with post-stroke spastic hemiplegia. Methods： A total of 86 cases of patients with post-stroke spastic hemiplegia were selected and divided into the control group and the trial group according to the random number table method， with 43 cases in each group. The control group was given rehabilitation training， and the trial group was additionally treated with acupoint catgut embedment based on the treatment of the control group. The two groups were treated for four weeks. The spasticity， upper limb function， activity of daily living and incidence of adverse reactions were compared between the two groups. Results： After four weeks of treatment，the scores of Modified Ashworth Scale (MAS) and Clinical Spasticity Index (CSI) in the two groups were decreased when compared with those before treatment，and the scores of MAS and CSI in the trial group were lower than those in the control group， differences being significant (P＜0.05). The scores of Carroll Upper Extremity Function Test (UEFT) and Fugl-Meyer Motor Function Assessment- Upper Extremity (FMA-UE) in the two groups were increased when compared with those before treatment， and the scores of UEFT and FMA-UE in the trial group were higher than those in the control group， differences being significant (P＜0.05). The scores of Modified Barthel Index (MBI) in the two groups were increased when compared with those before treatment， and the scores of Functional Activities Questionnaire (FAQ) were decreased when compared with those before treatment， differences being significant (P＜0.05)； the MBI score in the trial group was higher than that in the control group， and the FAQ score in the trial group was lower than that in the control group， differences being significant (P＜ 0.05). During treatment，the incidence of adverse reactions was 6.98% in the trial group，and there was no adverse reaction in the control group，there being no significance in the difference (P＞0.05). Conclusion： The therapy of acupoint catgut embedment combined with rehabilitation training can effectively mitigate the spasticity of patients with post-stroke spastic hemiplegia，and enhance the upper limb function and activity of daily living with great safety.