基于数据挖掘技术研究王付使用经方治疗胃癌用药规律
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R735.2

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青海省卫生健康委指导性课题(2022-wjzdx-20);青海省中青年人才托举工程(2022QHSKXRCTJ08)


Study on Medication Rule of WANG Fu in Using Formulas to Treat Gastric Cancer Based on Data Mining Technology
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    摘要:

    目的:研究王付使用经方治疗胃癌用药规律。方法:使用王付经方门诊大数据系统,搜集王付治 疗胃癌的门诊处方,使用Excel表格建立处方数据库,通过SPSS Modeler18.0、Cytoscape及R语言软件进行关联 规则和聚类分析。结果:共纳入王付治疗胃癌的处方515张,涉及中药109味,中药累计使用频次8 197次,使 用频次较高的中药依次是人参、甘草、半夏、黄芩、黄连。药物功效类别以补虚药、清热药、化痰止咳平喘药 为主,温热药多于寒凉、平性药,归经以脾、胃、肺经最多。关联规则中的药物均为半夏泻心汤核心药物,聚 类分析得到治疗胃癌基础方5张。结论:王付在运用经方治疗胃癌时攻补兼施、寒热并用、阴阳平调,常用基 础方有半夏泻心汤等,配合使用十八反药物,如人参-藜芦,附子-半夏,海藻-甘草,为深入挖掘经方在胃癌 治疗中的应用价值提供了启发和指导。

    Abstract:

    Abstract:Objective:To study the medication rule of WANG Fu in using formulas to treat gastric cancer based on data mining technology. Methods: The outpatient formulas of WANG Fu Jingfang in treating gastric cancer were collected via the Outpatient Big Data System of WANG Fu's Formulas. The formula database was established via Excel, and analysis of association rules and clustering were carried out by SPSS Modeler18.0, Cytoscape and R language software. Results: A total of 515 formulas in treating gastric cancer by WANG Fu were included,involving 109 kinds of Chinese herbs,and the cumulative use of Chinese herbs was 8 197 times. The most frequently used Chinese herbs were Ginseng Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Pinelliae Rhizoma,Scutellariae Radix and Coptidis Rhizoma. The main herbal effects were supplementing deficiency,clearing heat,dissolving phlegm and relieving cough as well as relieving panting. Warm herbs were more than cold herbs and neutral herbs, and in terms of channel entry,the spleen,stomach and lung channels were the most. The herbs obtained by association rules were all core drugs of Banxia Xiexin Decoction, and five basic formulas for treating gastric cancer were obtained by cluster analysis. Conclusion:When WANG Fu uses formulas to treat gastric cancer,he applies both attack and supplementation, simultaneous treatment with cold and warm herbs, and combination of yin and yang. He usually uses basic formulas including Banxia Xiexin Formula,and combines with herbs of eighteen antagonisms, such as Ginseng Radix et Rhizoma-Veratri Nigri Radix et Rhizoma, Aconiti Lateralis Radix Praeparata-Pinelliae Rhizoma, Sargassum-Glycyrrhizae Radix et Rhizoma, which provides inspiration and guidance for further exploring the application value of formulas in treating gastric cancer.

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牛晓骥,马丽娟,马铭悦,王帮民,王守梅,胡爱艳,徐怡,张树辉,指导:王付.基于数据挖掘技术研究王付使用经方治疗胃癌用药规律[J].新中医,2024,56(14):138-144

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  • 在线发布日期: 2024-07-28
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