Abstract： Objective： To observe the clinical effect of Dingshen Decoction combined with external application with Euodiae Fructus Powder on insomnia with the liver constraint and spleen deficiency syndrome during chemotherapy after surgery for breast cancer. Methods： A total of 80 cases of patients with insomnia with the liver constraint and spleen deficiency syndrome during chemotherapy after surgery for breast cancer were selected and divided into the control group and the treatment group according to the random number table method，with 40 cases in each group. The control group was treated with Estazolam Tablets， and the treatment group was additionally treated with the oral administration of Dingshen Decoction and the external application with Euodiae Fructus Powder based on the treatment of the control group. Both groups were treated for 14 days. Clinical effects， sleep quality， traditional Chinese medicine (TCM) syndrome scores，and the incidence of adverse reactions were compared between the two groups. Results：After 14 days of treatment，the total effective rate was 77.50% in the treatment group，higher than that of 52.50% in the control group， the difference being significant (P＜0.05). The scores of the Pittsburgh Sleep Quality Index (PSQI) in the two groups were decreased when compared with those before treatment， and the PSQI scores in the observation group were lower than those in the control group， differences being significant (P＜0.05). The TCM syndrome scores in the two groups were decreased when compared with those before treatment， and the TCM syndrome scores in the observation group were lower than those in the control group， differences being significant (P＜0.05). During treatment， the incidence of adverse reactions was 17.50% in the control group，lower than that of 37.50% in the control group，the difference being significant (P＜0.05). Conclusion：Dingshen Decoction combined with external application with Euodiae Fructus Powder can improve clinical effects on the treatment of insomnia during chemotherapy after surgery for breast cancer，effectively relieve clinical symptoms，improve sleep quality， and reduce adverse reactions.