Abstract： Ministerial fire originates from the theory of five circuits and six qi， which is one of the important concepts in the theories of Chinese medicine. Chinese medicine practitioners in the Tang and Song Dynasties associated it with the physiological and pathological changes of human body， and guided clinical practice ZHU Danxi，a Chinese medicine practitioner in the Jin and Yuan Dynasties，summarized the theoretical experience of predecessors and made a thorough interpretation of the theory of ministerial fire to systematize it. Most of the theories of various phases of ministerial fire in later generations were developed on this basis. Based on the theory of ministerial fire，the etiology and pathogenesis of non-alcoholic fatty liver disease are discussed from the physiology and pathology of ministerial fire in this paper. Clinical treatment of non-alcoholic fatty liver disease should be based on restoring the momentum of ministerial fire.