Abstract：Objective：To explore the medication rules of Chinese medicine in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure based on data mining. Methods： Clinical randomized controlled trials of Chinese medicine in the treatment of COPD complicated with respiratory failure from the date of database establishment to December 2021 in CNKI，Wanfang Database， and VIP Database were collected as the data sources. Traditional Chinese Medicine Inheritance Support System (V2.5) was used to analyze the rules of prescription and medication in Chinese medicine treatment. Modules such as formula analysis were used for data mining and analysis on the frequency of medicinal use， meridian entry， natures and flavors， prescription rules， core combinations， etc. Results： A total of 119 articles were included， involving 144 prescriptions and 175 Chinese medicinals. Medicinals with high frequency of use included Glycyrrhizae Radix et Rhizoma， Pinelliae Rhizoma， Poria， Armeniacae Semen Amarum， Citri Reticulatae Pericarpium， Astragali Radix， Atractylodis Macrocephalae Rhizoma， etc. The main meridian entries were the lung， spleen， and stomach meridians. The leading medicinal nature was warm， and the primary medicinal flavors were bitter and sweet. Common medicinal couplets included Pinelliae Rhizoma-Poria， Pinelliae Rhizoma-Glycyrrhizae Radix et Rhizoma， Glycyrrhizae Radix et Rhizoma-Poria，Atractylodis Macrocephalae Rhizoma- Glycyrrhizae Radix et Rhizoma，etc. A total of 12 core combinations were summarized. Conclusion：The Chinese medicine treatment of COPD complicated with respiratory failure is based on tonifying qi， supplemented by the method of banking up earth to generate metal， combined with medicinals for cough relief， phlegm reduction， asthma relief， heat clearing， and blood activating. It emphasizes the elimination of pathological products such as phlegm，blood stasis，and fluid retention. Such treatment reflects the Chinese medicine theoretical idea of reinforcing healthy qi and dispelling pathogens and treating both the root and branch of diseases.