基于数据挖掘总结林创坚治疗慢性非特异性腰痛用药规律
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R274.9

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广东省林创坚名中医传承工作室建设项目(粤中医办函〔2018〕05号);国家中医药管理局第七批全国老中医药专家学术经验继承工作 项目(国中医药人教函〔2022〕76号)


Medication Rules of LIN Chuangjian Treating Chronic Non-Specific Low Back Pain Based on Data Mining
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    摘要:

    目的:运用数据挖掘总结林创坚教授治疗慢性非特异性腰痛的用药规律。方法:收集林教授 2018年4月—2022年4月接诊的慢性非特异性腰痛病例,筛选建立数据库,使用古今医案云平台(V2.3.2) 进 行数据分析。结果:共纳入203首处方,涉及106味中药,药物记录共2 955条。其中出现频次>25次的高频 药物共有24味,药物的药性以温、平为主,药味以辛、甘、苦为主,主要归肝、肾、脾经。关联规则分析显 示支持度排行前5的组合是牛膝-独活、桑寄生-独活、藿香-独活、党参-独活、独活-厚朴。聚类分析得到 4个高频药物核心聚类组合,复杂网络分析得出核心方药为:独活、秦艽、厚朴、党参、藿香、甘草、牛膝、 桑寄生、杜仲、木瓜、威灵仙、白芷。结论:林教授治疗岭南慢性非特异性腰痛强调三因制宜,辨证用药,以 燥湿行气健脾、补肝肾强筋骨为原则,兼顾祛风散寒、补益气血,攻补并用,标本兼顾。

    Abstract:

    Abstract:Objective:To summarize the medication rules of Professor LIN Chuangjian treating chronic non-specific low back pain with data mining. Methods:Cases of chronic non-specific low back pain treated by Professor LIN from April 2018 to April 2022 were collected and screened to establish a database,which was analyzed by Ancient and Modern Medical Records Cloud Platform (V2.3.2). Results : A total of 203 prescriptions were included,involving 106 Chinese medicinals,with a total of 2 955 medicinal records. Among them, there were 24 high-frequency medicinals that appeared more than 25 times; the main medicinal natures were warm and neutral,and the medicinal flavors were mainly acrid,sweet,and bitter; the main meridian entries were the liver, kidney, and spleen meridians. The association rule analysis showed that the top five combinations in terms of support were Achyranthis Bidentatae Radix-Angelicae Pubescentis Radix, Taxilli Herba-Angelicae Pubescentis Radix, Pogostemonis Herba-Angelicae Pubescentis Radix, Codonopsis Radix-Angelicae Pubescentis Radix, and Angelicae Pubescentis Radix- Magnoliae Officinalis Cortex. Cluster analysis obtained four high frequency and core cluster combinations, and complex network analysis summarized the core prescriptions as follows:Angelicae Pubescentis Radix, Gentianae Macrophyllae Radix, Magnoliae Officinalis Cortex, Codonopsis Radix, Pogostemonis Herba, Glycyrrhizae Radix et Rhizoma, Achyranthis Bidentatae Radix, Taxilli Herba, Eucommiae Cortex, Chaenomelis Fructus, Clematidis Radix et Rhizoma, and Angelicae Dahuricae Radix. Conclusion: In the treatment of Lingnan area chronic non-specific low back pain, Professor LIN emphasizes three factors, namely the patients, the seasons, and the living environment of the patients; the medication should be adjusted according to syndromes. The principle is to dry dampness, move qi, and fortify the spleen, supplement the liver and kidney, and strengthen sinew and bone, while also taking into account the principles of dispelling wind and dissipating cold, nourishing qi and blood, using methods of attack and supplement,and dealing with both the root and branch of the disease.

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陈瀚,林创坚.基于数据挖掘总结林创坚治疗慢性非特异性腰痛用药规律[J].新中医,2024,56(15):6-12

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  • 在线发布日期: 2024-08-11
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