Abstract： Objective： To observe the clinical effect of modified Shengmai San combined with longsnake moxibustion for chronic persistent asthma with obesity. Methods：A total of 90 cases of patients with asthma with obesity were selected and divided into group A， B， and C according to the random number table method， with 30 cases in each group. group A was treated with modified Shengmai San， group B with medicinal long-snake moxibustion， and group C with modified Shengmai San and long-snake moxibustion. All groups were continuously treated for four weeks. Traditional Chinese medicine syndrome scores，Asthma Control Test (ACT) scores，lung function indicator [peak expiratory flow (PEF)，forced vital capacity (FVC)， and forced expiratory volume in the first second (FEV1)/FVC]， serological indicators [interleukin-6 (IL-6)，interleukin-18 (IL-18)，interferon-γ (INF-γ)，immunoglobulin E (IgE)，adiponectin， and leptin] were compared among the three groups before and after treatment； adverse reactions were compared among the three groups. Results： After treatment， traditional Chinese medicine syndrome scores in the three groups were declined (P＜0.05)， and the scores in group C were lower than those in groups A and B (P＜0.05)； ACT scores in the three groups were increased (P＜0.05)， and the scores in group C were higher than those in group A and B (P＜0.05)；there was no significant difference being found between group A and B (P＞0.05). After treatment， FVC， FEV1/FVC， and PEF in the three groups were improved (P＜0.05)，and the above indicators in group C were higher than those in group A and B (P＜0.05)； there was no significant difference being found between group A and B (P＞0.05). After treatment，IL-6， IL-18，IgE，and leptin in serum in the three groups were decreased (P＜0.05)，and the above indicators in group C were lower than those in group A and B (P＜0.05)； adiponectin， and INF- γ in the three groups were increased (P＜0.05)，and the above indicators in group C were higher than those in group A and B (P＜ 0.05)；there was no significant difference being found between group A and B (P＞0.05). No severe adverse reactions happened in the three groups. Conclusion：Modified Shengmai San and long-snake moxibustion for chronic persistent asthma with obesity can improve asthma，alleviate clinical symptoms，and enhance lung function. Its mechanism of action may be related to regulating the levels of cytokines and inflammatory factors，reducing inflammatory responses，and improving Chinese medicine constitution.