Abstract：Objective： To observe the effect of Qingre Pingchuan Decoction combined with γ-globulin on immune function and levels of Krebs von den Lungen-6 (KL-6) and lactate dehydrogenase (LDH) in serum in patients with severe acute viral pneumonia. Methods： A total of 123 patients with acute severe viral pneumonia were selected and divided into the Chinese medicine group，the western medicine group， and the combination group according to different treatment methods， with 41 cases in each group. The Chinese medicine group was treated with Qingre Pingchuan Decoction，the western medicine group was treated with γ -globulin， and the combination group was treated with Qingre Pingchuan Decoction combined with γ -globulin. The clinical effects and disappearance time of symptoms and signs were compared among the three groups. The changes in immune function， serum inflammatory factors [interleukin-2 (IL-2)，and tumor necrosis factor-α (TNF-α)]，matrix metalloproteinase-9 (MMP-9)，KL-6， and LDH were compared before and after treatment among the three groups. Results：The total effective rate of clinical effect was 95.12% in the combination group， which was higher than that in the Chinese medicine group and the western medicine group，and the difference was significant. The recovery time of body temperature， and the disappearance time of dyspnea， cough， and lung rales in the combination group were all shorter than those in the Chinese medicine group and the western medicine group，and the differences were significant (P＜0.05). After treatment， the levels of IgG， IgM， and IgA in the three groups were all increased when compared with those before treatment (P＜0.05)， and the above three levels in the combination group were higher than those in the Chinese medicine group and the western medicine group (P＜0.05). After treatment， the values of CD3+ ， CD4+ ， and CD4+/CD8+ in all the three groups were raised when compared with those before treatment (P＜0.05)， and the values of CD3+ ， CD4+，and CD4+/CD8+ in the combination group were higher than those in the Chinese medicine group and the western medicine group (P＜0.05). After treatment， the levels of IL-2 in all the three groups were increased when compared with those before treatment (P＜0.05)， and the TNF- α levels were decreased (P＜0.05). The IL-2 level in the combination group was higher than that in the Chinese medicine group and the western medicine group (P＜0.05)，and TNF-α level was lower than that in the Chinese medicine group and the western medicine group (P＜0.05). After treatment， the levels of KL-6， LDH， and MMP-9 protease in serum in the three groups were decreased when compared with those before treatment (P＜ 0.05)，and the levels of KL-6，LDH，and MMP-9 protease in serum in the combination group were lower than those in the Chinese medicine group and the western medicine group (P＜0.05). Conclusion： The combination of Qingre Pingchuan Decoction and γ-globulin can regulate the immune function of patients with acute severe viral pneumonia，alleviate inflammatory reactions，reduce serum KL-6 and LDH levels， improve therapeutic effects，and promote rehabilitation.