Abstract： Objective： To observe the clinical effect of Yizhong Tiaoda Prescription combined with conventional western medicine on chronic ischemic colitis (IC) of liver constraint and spleen deficiency type. Methods：A total of 72 cases of patients with chronic IC of liver constraint and spleen deficiency type were selected and divided into the trial group and the control group by random number table method ， with 36 cases in each group. The control group was treated with conventional western medicine， and the trial group was given oral administration with Yizhong Tiaoda Prescription. Both groups were treated for two weeks. The main symptom scores，levels of white blood cell count (WBC)，hemoglobin (Hb)，C-reactive protein (CRP)， and severity grading of intestinal mucosal lesions under colonoscopy were compared between the two groups before and after treatment. Results： After treatment， the scores of abdominal pain degree， frequency of diarrhea， and rectal bleeding time， as well as the total scores of main symptoms in the two groups were decreased when compared with those before treatment (P＜0.05)，and each score in the trial group was lower than that in the control group (P＜0.05). After treatment，the levels of WBC and CRP in the two groups were reduced when compared with those before treatment， and Hb levels were increased (P＜0.05)；the levels of WBC and CRP in the trial group were lower than those in the control group， and Hb level in the trial group was higher than that in the control group (P＜0.05). After treatment， the severity grading of intestinal mucosal lesions under colonoscopy in the two groups was improved when compared with that before treatment (P＜0.05)， and the severity grading of intestinal mucosal lesions under colonoscopy in the trial group was better than that in the control group (P＜0.05). Conclusion： Yizhong Tiaoda Prescription combined with conventional western medicine has good clinical effects on chronic IC of liver constraint and spleen deficiency type， which can effectively relieve clinical symptoms of patients，reduce inflammatory responses，and improve intestinal mucosal lesions.