Abstract： Objective： To observe the clinical effect of Yiqi Jianpi Huashi Decoction in the adjuvant therapy of diabetic kidney disease (DKD) with the syndrome of spleen deficiency and prevalence of dampness and its effects on transforming growth factor- β1 (TGF- β1)， urinary connective tissue growth factor (CTGF)， and fibronectin (FN) in serum. Methods： The DKD patients with the syndrome of spleen deficiency and prevalence of dampness were divided into the observation group and the control group according to the random number table method， with 55 cases in each group. The control group received conventional western medicine，and the observation group was additionally treated with Yiqi Jianpi Huashi Decoction based on the treatment of the control group. Both groups were continuously treated for one month. Clinical effects， as well as traditional Chinese medicine (TCM) syndrome scores， blood glucose indicators [fasting blood glucose (FBG)，2-hour postprandial blood glucose (P2hBG)，and hemoglobin A1C (HbA1c)]， serum renal fibrosis indicators (TGF- β1， CTGF， and FN)， kidney function indicators [serum creatinine (SCr)， estimated glomerular filtration rate (eGFR)， and blood urea nitrogen (BUN)] before and after treatment were compared between the two groups. Results：After treatment，the total effective rate in the observation group was higher than that in the control group (P＜0.05). After treatment， TCM syndrome scores and the levels of FBG， P2hBG， HbA1c， TGF- β1， CTGF， FN， SCr， and BUN in the two groups were reduced when compared with those before treatment (P＜0.05)，and the levels of eGFR were increased (P＜0.05)；TCM syndrome scores，levels of TGF- β1，CTGF，FN，SCr，and BUN blood glucose indicators in the observation group were lower than those in the control group (P＜0.05)，and the level of eGFR in the observation group was higher than that in the control group (P＜0.05). Conclusion：Yiqi Jianpi Huashi Decoction has a definite curative effect in the adjuvant therapy of DKD with the syndrome of spleen deficiency and prevalence of dampness， which can effectively control the levels of blood glucose and improve renal fibrosis and kidney function.