Abstract： Objective： To observe the clinical effect of rubbing of Chinese herbal prescriptions on diabetic peripheral neuropathy. Methods： A total of 102 patients with diabetic peripheral neuropathy were divided into the western medicine group and the Chinese and western medicine group according to randomized double-blind method，with 51 cases in each group. The western medicine group was treated with conventional western medicine， and the Chinese and western medicine group was treated with conventional western medicine and rubbing of Chinese herbal prescriptions. The Wagner grading，scores of Toronto Clinical Scoring System (TCSS)， neuroelectrophysiological indexes (motor nerve conduction velocity，sensory nerve conduction velocity of median nerve and sural nerve) and oxidative stress indexes (superoxide dismutase， total antioxidant capacity， malonaldehyde) before and after treatment as well as the clinical effects were compared between the two groups. Results： The component ratio of Wagner Grade 0 in the Chinese and western medicine group was 100%，higher than that of 92.16% in the western medicine group (P＜0.05). After treatment，each score of TCSS and the total scores in the two groups were decreased (P＜0.05)， and the above scores in the Chinese and western medicine group were lower than those in the western medicine group (P＜0.05). After treatment， the movement and sensory nerve conduction velocity of median nerve and sural nerve were increased in both groups (P＜0.05)， and the above indexes in the Chinese and western medicine group were higher than those in the western medicine group (P＜0.05). After treatment，the levels of superoxide dismutase in the two groups were increased (P＜ 0.05)，and the above level in the Chinese and western medicine group was higher than that in the western medicine group (P＜0.05)； the levels of total antioxidant capacity and malondialdehyde in the two groups were reduced (P＜0.05)，and the above levels in the Chinese and western medicine group were lower than those in the western medicine group (P＜0.05). After treatment，the total effective rate was 94.12% in the Chinese and western medicine group，higher than that of 80.39% in the western medicine group (P＜0.05). Conclusion：Rubbing of Chinese herbal prescriptions has a significant therapeutic effect on treating diabetic peripheral neuropathy， which can significantly reduce the clinical symptoms of patients and improve the neuroelectrophysiological indexes and oxidative stress indexes.