Abstract： Objective： To explore the effect of Huangzhi Yishen Capsules combined with Piperazine Ferulate Tablets on chronic glomerulonephritis. Methods： A total of 96 cases of patients with chronic glomerulonephritis were divided into two groups according to the random number table method ， with 48 cases in each group. The western medicine group was treated with Piperazine Ferulate Tablets，and the combined group with Huangzhi Yishen Capsules combined with Piperazine Ferulate Tablets. Traditional Chinese medicine syndrome scores，T lymphocyte subsets and kidney function indexes were compared in two groups； clinical effects and adverse reactions were compared. Results： The effective rate was 97.92% in combined group， higher than that of 85.42% in western medicine group (P＜0.05). After treatment， the scores of traditional Chinese medicine syndromes in the two groups were decreased(P＜ 0.05)， and the scores in combined group were lower(P＜0.05). CD3+ ， CD4+ ， and CD4+/CD8+ in the two groups were increased， and CD8+ levels were decreased (P＜0.05)； CD3+ ， CD4+ ， and CD4+/CD8+ in combined group were higher， and CD8+ was lower(P＜0.05). After treatment， the levels of blood urea nitrogen (BUN)，serum creatinine (SG) and glomerular filtration rate (GFR) in the two groups were decreased (P＜0.05)， and the above levels in combined group were lower(P＜0.05). The rate of adverse reactions in combined group (4.17%) was lower than that in western medicine group (18.75%) (P＜0.025). Conclusion： Huangzhi Yishen Capsules combined with Piperazine Ferulate Tablets for chronic glomerulonephritis can enhance clinical effects， improve kidney function and clinical symptoms and regulate immune function， with high safety.