Abstract： Objective： To observe the clinical effect of Pudilan Xiaoyan Oral Liquid combined with Acyclovir and interferon α-2b on children with herpetic angina. Methods： A total of 104 cases of children with herpetic angina were divided into the observation group and the reference group according to the random number table method， with 52 cases in each group. The reference group was treated with Acyclovir combined with interferon α-2b，and the observation group was additionally treated with Pudilan Xiaoyan Oral Liquid based on the treatment of the reference group. The clinical effects and the remission time of symptoms were compared between the two groups； traditional Chinese medicine syndrome scores，serum inflammatory factors and immunoglobulin levels before and after treatment were compared between the two groups. Results： The total effective rate was 96.15% in the observation group， higher than that of 82.69% in the reference group (P＜0.05). After treatment， traditional Chinese medicine syndrome scores in the two groups were decreased (P＜0.05)，and the score in the observation group was lower than that in the reference group (P＜0.05). The antipyretic time，the disappearance time of pain，the regression time of herpes， and the recovery time of appetite in the observation group were shorter than those in the reference group (P＜0.05). After treatment，the levels of interleukin-6 (IL-6)，interleukin-10 (IL-10) and tumor necrosis factor- α (TNF- α) in serum in the two groups were decreased (P＜0.05)， and the above levels in the observation group were lower than those in the reference group (P＜0.05). After treatment，the levels of immunoglobulin A (IgA)，immunoglobulin G (IgG) and immunoglobulin M (IgM) in serum in the two groups were increased (P＜0.05)， and the above levels in the observation group were higher than those in the reference group (P＜0.05). Conclusion ： Pudilan Xiaoyan Oral Liquid combined with Acyclovir and interferon α-2b has a significant curative effect on children with herpetic angina， which can promote their improvement of symptoms and signs，reduce body's inflammatory responses and enhance immune function.