Abstract： Objective： To observe the clinical effect of Qingre Jianpi Lishi Prescription combined with conventional western medicine on chronic eczema of spleen deficiency and dampness accumulation type. Methods： A total of 96 cases of patients with chronic eczema were selected and divided into the control group and the study group by random number table method， with 48 cases in each group. The control group was treated with conventional western medicine， and the research group was additionally given Qingre Jianpi Lishi Prescription based on the treatment of the control group. The clinical effects in the two groups were evaluated；the recurrence rates were analyzed；traditional Chinese medicine (TCM) syndrome scores，12-Item Pruritus Severity Scale (12-PSS) scores，Eczema Area and Severity Index (EASI) scores before and after treatment were compared between the two groups. The skin barrier function indexes， immune function and inflammatory factors in the two groups were detected. Results： The total effective rate in the study group was 97.92%，which was higher than that of 83.33% in the control group (P＜0.05). The recurrence rate was 7.69% in the study group， lower than that of 66.67% in the control group (P＜ 0.05). After treatment，TCM symptom scores in the two groups were reduced when compared with those before treatment (P＜0.05)， and the TCM symptom score in the study group was lower than that in the control group (P＜0.05). After treatment，the scores of 12-PSS and EASI in the two groups were decreased when compared with those before treatment (P＜0.05)， and the scores of 12-PSS and EASI in the study group were lower than those in the control group (P＜0.05). After treatment， the Trans Epidermal Water Loss (TEWL) in the two groups was declined when compared with that before treatment，and the TEWL in the study group was lower than that in the control group (P＜0.05). The cuticle water content and sebum content in the two groups were increased when compared with those before treatment， and the cuticle water content and sebum content in the study group were higher than those in the control group (P＜0.05). After treatment， the levels of Th1/Th2， interleukin-6 receptor (IL-6R)， leukotriene B4 (LTB4) and Fas ligand (Fas-L) in the two groups were reduced when compared with those before treatment (P＜0.05)；the levels of Th1/Th2，IL-6R，LTB4 and Fas-L in the study group were lower than those in the control group (P＜0.05). Conclusion： The combination of Qingre Jianpi Lishi Prescription and conventional western medicine in the treatment of patients with chronic eczema with spleen deficiency and dampness accumulation syndrome can improve the skin barrier function， regulate the immune balance of peripheral blood cells， reduce the levels of inflammatory factors， improve the degree of itching， alleviate the disease，enhance the clinical effects，and reduce the recurrence rate.