Abstract： TCM clinical thinking and method is not only an important part of TCM education and personnel training， but also a key factor affecting the inheritance of TCM. Therefore， strengthening the cultivation of TCM clinical thinking has gradually become an urgent problem for TCM education that needed to be worked out. On the basis of undertaking related research and teaching activities，Research Room of TCM clinical thinking in the Second Clinical Medical School of Guangzhou University of Chinese Medicine constructed the teaching course of TCM Clinical Thinking and Method， which takes TCM thinking methodology as academic guidance， unearthed literature as academic source， and handed down ancient classics as academic foundation. It explores the teaching method of TCM clinical thinking and method， which combines phased， practice-focused， and case-based learning (CBL) with project-based learning (PBL)，and has achieved some results. This article introduces the experience and results of the exploration and practice of the construction of the course.