Abstract： Objective： To observe the clinical effect of the therapy of modified Zhenwu Decoction combined with western medicine on peritoneal dialysis (PD) complicated with chronic heart failure (CHF) with syndrome of yang deficiency with water flood. Methods： A total of 54 PD cases of patients complicated with CHF with syndrome of yang deficiency with water flood were selected and divided into the control group and the observation group according to the random number table method，with 27 cases in each group. During the study， two and three cases were culled in the control group and the observation group respectively，and finally 25 and 24 cases were included in each group. The control group was treated with routine western medicine，and the observation group was additionally treated with modified Zhenwu Decoction based on the treatment of the control group. Both groups were treated for 24 weeks. The clinical effects，traditional Chinese medicine (TCM) syndrome scores，and levels of heart function indexes [brain natriuretic peptide (BNP) and Galectin-3] were compared between the two groups. Results：After 24 weeks of treatment，the total effective rate was 79.17% in the observation group，higher than that of 28.00% in the control group，the difference being significant (P＜0.05). The TCM syndrome scores in the observation group were reduced when compared with those before treatment and were lower than those in the control group， differences being significant (P＜0.05)； there was no significant difference being found in the comparison of TCM syndrome scores in the control group with those before treatment (P＞0.05). The levels of serum BNP and Galectin-3 in the observation group were down-regulated when compared with those before treatment and were lower than those in the control group，differences being significant (P＜0.05)； there was no significant difference being found in the comparisons of levels of serum BNP and Galectin-3 in the control group with those before treatment (P＞0.05). Conclusion： The therapy of modified Zhenwu Decoction combined with western medicine has a great clinical effect on PD complicated with CHF with syndrome of yang deficiency with water flood， which can effectively improve the clinical symptoms and decrease the levels of serum BNP and Galectin-3.