Abstract：Objective：To observe the clinical effect of Danzhi Xiaoyao Powder combined with Sertraline Tablets on senile insomnia of liver constraint transforming into fire type and its effect on levels of 5- hydroxytryptamine (5-HT) and dopamine (DA) in serum. Methods： A total of 98 senile patients with insomnia of liver constraint transforming into fire type were divided into the combination group and the control group according to the random number table method， with 49 cases in each group. The control group was treated with basic treatment combined with Sertraline Hydrochloride Tablets， and the combination group was additionally treated with Danzhi Xiaoyao Powder based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores， Pittsburgh Sleep Quality Index (PSQI)，Hamilton Anxiety Scale (HAMA)，and the levels of 5-HT and DA were compared before and after treatment between the two groups. The clinical effects， recurrence rates， and safety were analyzed. Results：The total effective rate was 91.84% in the combination group，and 75.51% in the control group， the difference being significant (P＜0.05). After treatment，the scores of TCM syndromes such as insomnia and excessive dreaming，restlessness and irritability，headache and red face，red eyes and bitter mouth， chest tightness and hypochondriac pain，constipation and redness in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome scores in the combination group were lower than those in the control group (P＜0.05). After treatment，the PSQI and HAMA scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the score in the combination group was lower than that in the control group (P＜0.05). After treatment，the serum DA levels in the two groups were decreased when compared with those before treatment (P＜0.05)，and the DA level in the combination group was lower than that in the control group (P＜0.05). The 5-HT levels in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and 5-HT level in the combination group was higher than that in the control group (P＜0.05). The combination group had no recurrence cases，and the control group had a recurrence rate of 50.00%，the difference being significant (P＜0.05). During the treatment period， there were no significant adverse reactions observed in the two groups. Conclusion：Danzhi Xiaoyao Powder combined with Sertraline Tablets has a better curative effect on insomnia in senile patients of liver constraint transforming into fire type than simple western medicine treatment. It can effectively regulate the secretion of neurotransmitters， improve sleep quality， alleviate anxiety levels，and have a low recurrence rate and good safety.