Abstract： Objective： To observe the clinical effect of Changge Buyang Huanwu Decoction assisting conventional western medicine on acute cerebral infarction (ACI). Methods：A total of 108 ACI patients were divided into the treatment group and the control group according to the random number table method，with 54 cases in each group. The control group was treated with conventional western medicine for antihypertension， lipid-lowering， anti-platelet aggregation， nutrition of brain nerve， and the treatment group was additionally treated with Changge Buyang Huanwu Decoction based on the treatment of the control group. After two weeks of treatment， the clinical effects， blood viscosity， levels of serum inflammatory factors [interleukin-6 (IL-6) and hyper sensitive C-reactive protein (hs-CRP)]， degree of neurological impairment [scores of National Institute of Health Stroke Scale (NIHSS)] and activity of daily living [scores of Modified Barthel Index (MBI)] were compared between the two groups. Results： After treatment， the total effective rate was 94.44% in the treatment group and 77.78% in the control group， the difference being significant (P＜0.05). After treatment，the levels of blood viscosity，low-shear whole blood viscosity and high-shear whole blood viscosity in the two groups were reduced when compared with those before treatment (P＜0.05)，and the above three levels in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of serum IL-6 and hs-CRP in the two groups were declined when compared with those before treatment (P＜0.05)， and the above two levels in the treatment group were lower than those in the control group (P＜0.05). After treatment，the NIHSS scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the MBI scores were enhanced when compared with those before treatment (P＜0.05)； the NIHSS score in the treatment group was lower than that in the control group (P＜0.05)，and the MBI score was higher than that in the control group (P＜0.05). Conclusion： Changge Buyang Huanwu Decoction assisting conventional western medicine has a definite curative effect on ACI，which can improve the blood viscosity of patients， mitigate the inflammatory responses，and enhance the neurological impairment symptoms and the activity of daily living.