Abstract：Objective：To observe the clinical effect of Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation on insomnia with non-interaction between the heart and the kidney syndrome after cerebral stroke. Methods： A total of 90 cases of patients with insomnia with noninteraction between the heart and the kidney syndrome after cerebral stroke were selected and divided into the control group and the trial group according to the random number table method，with 45 cases in each group. In the control group， four cases were excluded and 41 cases were included， and repetitive transcranial magnetic stimulation was given. In the trial group， three cases were excluded and 42 cases were included，and patients were treated with Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation. Both groups were treated for four weeks. The clinical effects，Pittsburgh Sleep Quality Index (PSQI) scores， traditional Chinese medicine (TCM) syndrome scores， Berlin Questionnaire (BQ) scores and serum melatonin levels were compared between the two groups. Results： After four weeks of treatment， the total effective rate was 95.24% in the trial group， higher than that of 78.05% in the control group (P＜0.05). The PSQI scores，TCM syndrome scores and BQ scores in the two groups were decreased when compared with those before treatment， and PSQI score， TCM syndrome score and BQ score in the trial group were lower than those in the control group (P＜0.05). The serum melatonin levels in the two groups were increased when compared with those before treatment (P＜0.05)， and the serum melatonin level in the trial group was higher than that in the control group (P＜0.05). Conclusion： Zishen Ningxin Anshen Decoction combined with repetitive transcranial magnetic stimulation for insomnia with non-interaction between the heart and the kidney syndrome after cerebral stroke can enhance the therapeutic effect， improve sleep quality and sleep-related breathing disorders， relieve clinical symptoms，and regulate melatonin levels.