Abstract：Objective：To observe the clinical effect of Bugu Shujin Decoction combined with Zhengqing Fengtongning Sustained-Release Tablets on kidney yang deficiency rheumatoid arthritis. Methods：A total of 72 patients with rheumatoid arthritis of kidney yang deficiency were selected and divided into the study group and the control group according to random number table method，with 36 cases in each group. The control group was treated with Leflunomide，and the study group was treated with Bugu Shujin Decoction combined with Zhengqing Fengtongning Sustained-Release Tablets. The clinical effects， traditional Chinese medicine (TCM) syndrome scores，Visual Analogue Scale (VAS) scores，morning stiffness time， improvement of hand grip strength，and levels of serum rheumatoid factor (RF)，C-reactive protein (CRP) and interleukin-6 (IL-6) were compared between the two groups. Results： The total effective rate was 86.11% in the study group and 63.89% in the control group，the difference being significant (P＜0.05). After treatment，the TCM syndrome scores of joint tenderness，morning stiffness and fear of cold，pale tongue and white coating in the two groups were decreased when compared with those before treatment (P＜ 0.05)， and the TCM syndrome scores in the study group were lower than those in the control group (P＜ 0.05). After treatment， the levels of serum RF， CRP and IL-6 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of RF，CRP and IL-6 in the study group were lower than those in the control group (P＜0.05). After treatment， the VAS scores and morning stiffness time in the two groups were decreased when compared with those before treatment (P＜0.05)， and hand grip strength was increased when compared with that before treatment (P＜0.05)；the VAS score and morning stiffness time in the study group were lower than those in the control group (P＜0.05)， and hand grip strength was larger than that in the control group (P＜0.05). Conclusion：Bugu Shujin Decoction combined with Zhengqing Fengtongning Sustained-Release Tablets can significantly relieve the clinical symptoms of patients with kidney yang deficiency rheumatoid arthritis， improve joint function， reduce inflammation and RF damage.