Abstract： Objective： To observe the clinical effect of the combination use of Kechuanning acupoint application，Kangmin Zhike Prescription and Salmeterol/Fluticasone on cough variant asthma (CVA) of windcold type. Methods：A total of 100 cases of CVA patients of wind-cold type were respectively assigned to the control group and the combination group according to the random number table method，with 50 cases in each group. Four and three cases were respectively culled in the control group and the combination group， and finally 46 and 47 cases were included in each group. The control group was treated with Salmeterol/ Fluticasone for eight weeks， and the combination group was firstly treated with Salmeterol/Fluticasone combined with Kechuanning acupoint application for four weeks and then given oral administration of Kangmin Zhike Prescription for four weeks. The scores of cough-related symptoms， the levels of forced expiratory volume in one second (FEV1)，peak expiratory flow (PEF)，fractional exhaled nitric oxide (FeNO)， eosinophilic granulocyte (EOS)，immunoglobulin E (lgE)，interleukin-4 (IL-4) and tumor necrosis factor- α (TNF-α)，and the recurrence rate were compared between the two groups. Results：After treatment，the scores of cough-related symptoms in both groups were reduced when compared with those before treatment (P＜0.05)，there being no significance in the difference between the two groups (P＞0.05). After treatment， the levels of FEV1 and PEF in both groups were elevated when compared with those before treatment (P＜0.05)， and the FeNO levels were down-regulated when compared with those before treatment (P＜0.05)； there was no significant difference being found in the comparisons of levels of FEV1 and PEF between the two groups (P＞0.05)；the FeNO level in the combination group was lower than that in the control group (P＜0.05). After treatment， the levels of serum EOS， IgE， IL-4 and TNF- α in both groups were reduced when compared with those before treatment (P＜0.05)，and the above four levels in the combination group were lower than those in the control group (P＜0.05). Upon 12 weeks of follow-up after treatment，the recurrence rate was 8.51% in the combination group，lower than that of 23.91% in the control group (P＜0.05). During treatment， the adverse reactions happened to five cases in the control group and one in the combination group. Conclusion： The combination use of Kechuanning acupoint application， Kangmin Zhike Prescription and Salmeterol/Fluticasone can improve the cough-related symptoms and lung function of CVA patients of wind-cold type， mitigate the inflammation and decrease the recurrence rate.