Abstract： Objective： To observe the clinical effect of the therapy of external application of Dahuang Mangxiao Powder combined with point application on acute pancreatitis (AP) of liver constraint and qi stagnation type and its effect on levels of serum amylase (AMS) and inflammatory factors [interleukin-6 (IL-6) and C-reactive protein (CRP)]. Methods：A total of 96 AP patients of liver constraint and qi stagnation type were selected and divided into the trial group and the control group according to the random number table method，with 48 cases in each group. The control group was additionally treated with Somatostatin except for routine treatment， and the trial group was additionally treated with external application of Dahuang Mangxiao Powder combined with point application based on the treatment of the control group. The clinical effects in the two groups， the incidence of adverse reactions during the treatment， and the changes in disappearance time of symptoms， recovery time of gastrointestinal function， and levels of serum AMS， IL-6 and CRP before and after treatment were observed. Results：After treatment，the total effective rate was 95.83% in the trial group，and 77.08% in the control group，the difference being significant (P＜0.05). After treatment， the disappearance time of abdominal distention and pain， nausea and fever in the trial group was respectively shorter than that in the control group (P＜0.05). After treatment，the recovery time of gurgling sound， gastrointestinal peristalsis， spontaneous farting and defecation was obviously shorter than that in the control group (P＜0.05). After treatment，the levels of serum AMS，IL-6 and CRP in both groups were reduced when compared with those before treatment (P＜0.05)，and the above three levels in the trial group were lower than those in the control group (P＜0.05). The incidence of adverse reactions was 8.33% in the trial group and 16.67% in the control group，there being no significance in the difference (P＞ 0.05). Conclusion： The therapy of external application of Dahuang Mangxiao Powder combined with point application has a great curative effect on AP of liver constraint and qi stagnation type， which can downregulate the levels of inflammatory factors，improve the gastrointestinal function with great function，and promote the mitigation of clinical symptoms.