Abstract： This paper introduces Professor DENG Gaopi's clinical experience in treating premature ovarian insufficiency. Professor DENG Gaopi believes that the basic pathogenesis of premature ovarian insufficiency is kidney deficiency， liver depression， and blood deficiency， combined with spleen deficiency， liquid depletion， and blood stasis. In clinic， he attaches great importance to tonifying the kidney and regulating the liver，supplementing both essence and blood，and adeptly using autumn berrytype Chinese medicinals with strong taste to nourish the liver and kidney，which also nourish the spleen and stomach， and serve as the source of generating and transforming qi and blood. The treatment methods include： soothing the liver and relieving depression， regulating the flow of qi； invigorating blood and dissolving stasis， removing old and promoting new growth； nourishing the lung and stomach， and promoting fluid production and moistening dryness.